Adjuvant Effect of Whole-Cell Pertussis Component on Tetanus Toxoid Potency in Murine Model

There is currently an increasing interest in the development of new-generation purified antigen-based vaccines with a higher safety profile compared to conventional inactivated vaccines. The main problem subunit their lower immunogenicity whole-cell and inducing weaker shorter-lasting immune responses. In this paper, results assay potency tetanus component combined diphtheria pertussis vaccine (DTwP), (DT), monovalent (T) are presented. mice model, adjuvant impact on response against was observed. It noticed that DTwP significantly than DT T vaccines, despite same bounding ability unit toxoid formulations. levels induction antibodies by tested were also examined. no differences humoral responses This publication discusses possible mechanisms other antigens positive negative aspects using as adjuvant.